A Modern trial has test seven dissimilar vaccines as the booster for people who received either two doses of the Pfizer - BioNTech or the Oxford - AstraZeneca vaccine . The data shows that all relay link were well tolerated , and all but one produce a strong resistant response .
The results of the phase 2 trial run are account inThe Lancet . Seven takeoff booster vaccines and one control were administered to the 2,878 participants in the UK , with the third doses given 10 - 12 weeks after the initial two - dose course of the approved vaccinum .
The data show the immune response after 28 daytime – the event of boosters onlonger - terminal figure immunityis currently strange . But , data collected after three months will be put out in the Modern year .
The side effects are primarily heftiness soreness , pain at the shot situation , and fatigue , similar to those of the two - dose COVID-19 vaccine and other type of vaccinations . masses over the age of 70 appeared to experience fewer side effects compared to the younger cohort .
" The side effect data show all seven vaccines are safe to use as 3rd dot , with acceptable tier of seditious side effects like injectant web site pain , muscle soreness , fatigue . Whilst all boosted spike protein immunogenicity after two doses of AstraZeneca , only AstraZeneca , Pfizer - BioNTech , Moderna , Novavax , Janssen and Curevac did so after two STD of Pfizer - BioNTech , " Professor Saul Faust , run lead and Director of the NIHR Clinical Research Facility , University Hospital Southampton NHS Foundation Trust , said in astatement .
" It ’s really encouraging that a broad compass of vaccines , using different technologies , show benefit as a third dose to either AstraZeneca or Pfizer - BioNTech . That give self-confidence and flexibility in develop booster programme here in the UK and globally , with other broker like supply chemical chain and logistics also in play . "
The study has limitation due to the pandemic timeline . The boosters were given much earlier than current insurance DoS , something being accost in a test amendment . The participants were also older than the general population ( all were over 30 ) and were mostly white . Further work will be necessary .
